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INTRODUCTORY STATEMENT

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THE FUNCTIONAL CARBONYL GROUP IN PATHOGENESIS

AND ITS REVERSAL

 

By, William F. Koch, Ph.D., M.D.

 

INTRODUCTORY STATEMENT

In tissue chemistry there is scarcely a reaction that does not involve or produce a Carbonyl group as an intermediary or as an end product. And yet its significance in energy production has been overlooked, except in a passing way, by nearly all biochemists. Many Carbonyl groups do not hold vitally critical posi­tions, and indeed only a few are of deep interest to us. However, these take preference above all other Carbonyl groups in the tissue metabolism by the fact that they are “activated.” By activation, we mean that their inherent prop­erties have been accentuated, giving them the advantage of being able to car­ry through all the reactions they are disposed to mediate.

 

One property is the electro-negativity they possess by virtue of being able to attract and accumulate electrons in the carbon-oxygen double bond. These are mobile electrons, and are designated by the Greek letter (pi), which are enhanced by migrations of electrons from other electron-contributing groups in the molecule, and by electron attracting groups that influence external electrons. For our short discussion, we must avoid the many other associated properties though they admit of mathematical expression and hold a great theoretical interest. Those that we will deal with are of high interest to us in matters of health and happiness, our ability to maintain good vitality, and be­cause of the place they hold in the cure of all forms of disease, as it affects all cellular life from the smallest microorganisms to the highest adult tissue cells. They hold the position of a Least Common Denominator by initiating the normal aerobic metabolism of function and nutrition and hence, their unabridged activity eliminates parasitism in microorganisms, tissue cells, and in the virulency associated with pathogenicity.

They thus hold a key position in the great biological economy, and this is due to the fact that they serve as the initiators of oxidative energy production for function and nutrition. And when not blocked in this action, they do away with the need for parasitism in microorganisms and in tissue cells and thus, when this ability is restored, pathogenicity is eliminated from bacteria and neoplasia can no longer exist in the tissue cells. So the best way to get rid of infectious disease and neoplasia, is to cure the germ or tissue cell of its metabolic deficiency. The purpose now is to show how that is done.


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